10 Jun Linear regression habits were used to evaluate dating between D l
Beliefs is actually form (SD) for all variables but sex and you may race, which are represented from the frequency and you can percent on the given kinds
Subjects born at between 23 and 30 weeks of gestation and having a diagnosis of BPD were recruited from the Neonatal Intensive Care Unit or the Pediatric Pulmonary Clinic of James Whitcomb Riley Hospital for Children (Indianapolis, IN) between 2008 and 2012. BPD was defined as an oxygen requirement (>21% F i O2) for at least 28 days. Subjects were clinically stable outpatients with no oxygen requirement at the time of testing and no acute respiratory symptoms for at least 3 weeks.
Subjects born during the 37 weeks of gestation or after was in fact recruited using ads when you look at the regional publications in Indianapolis, Indiana, ranging from 2008 and you may 2013. The subjects had no cardiorespiratory malformations, and all had a respiratory record bad to possess wheezing, symptoms of asthma, treatment with asthma medicines, otherwise hospitalization to have a breathing infection.
Subjects were evaluated between 2008 and 2013 at James Whitcomb Riley Hospital for Children while sleeping in a supine position with chloral hydrate sedation (50–100 mg/kg). Oxygen saturation and heart rate were monitored during testing as recommended in American Thoracic Society/European Respiratory Society guidelines (13). The study was approved by the institutional review board at Indiana University, and parental informed consent was obtained. D l CO values measured on room air were previously reported for 18 subjects with BPD and 25 FT infants (8, 14).
D l CO and V a were measured using normoxic (20% oxygen, 4% helium, and 0.3% CO 18 ) and hyperoxic (90% oxygen, 4% helium, and 0.3% CO 18 ) test gases and a 4-second induced respiratory pause at an inflation airway pressure of 30 cm H2O, as previously described (8, 14, 15).